Naturium's moisturizer names peptides first, then vitamin C and panthenol. The declaration puts a different ingredient ahead of all of them. Niacinamide is eighth. The first peptide is tenth.
The actives, in label order
The published list has 48 ingredients. After water, glycerin, dimethicone, jojoba oil, squalane and two fatty-alcohol emulsifiers, the actives begin:
| Pos. | Ingredient (INCI) | What it is | Molecular weight | PubMed |
|---|---|---|---|---|
| 8 | Niacinamide | vitamin B3 | 122.1 g/mol | 45 RCTs (topical) |
| 10 | Palmitoyl Tripeptide-5 | sold as Syn-Coll | 611.9 g/mol | 4 records |
| 12 | Palmitoyl Tripeptide-1 | Matrixyl 3000, first half | 578.8 g/mol | see entry |
| 13 | Palmitoyl Tetrapeptide-7 | Matrixyl 3000, second half | 694.9 g/mol | see entry |
| 14 | Hydrolyzed Plukenetia Volubilis Seed Extract | sacha inchi seed extract | mixture | — |
| 15 | Dunaliella Salina Extract | microalga extract | mixture | — |
| 16 | Sodium Hyaluronate | humectant | polymer | — |
| 17 | 3-O-Ethyl Ascorbic Acid | stabilised vitamin C derivative | — | 25 records |
| 18 | Panthenol | provitamin B5 | — | — |
Weights from PubChem; counts via NCBI E-utilities, run 2026-09-17. Pantolactone sits at 11, between the first and second peptide. Stearyl alcohol at 9 separates niacinamide from the peptides.
The two Matrixyl 3000 peptides have their own evidence entries: palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, each of which finds no human trial testing the peptide on its own. How three different products came to share the Matrixyl name is on our Matrixyl entry.
The third peptide
Palmitoyl tripeptide-5 is the one peptide in this formula the site has not covered before. PubChem gives it as 611.9 g/mol, above the 500-dalton line our skin-peptide evidence page explains. It is sold under the trade name Syn-Coll.
PubMed held four records naming it on 2026-09-17, and every one sets it among other things:
- A 2025 study of supramolecular collagen nanoparticles for wrinkles, whitening and moisture (Colloids Surf B).
- A 2023 study of self-healing hydrogels as a delivery vehicle for active peptides (Molecules).
- A 2021 review of synthetic peptides in sensitive-skin cosmetics (Pharmaceuticals), the same review our palmitoyl tetrapeptide-7 entry cites for its finding that the data sit mostly in patents and supplier documents.
- A 2020 microneedle patch study of peptides loaded on hyaluronic acid (J Cosmet Dermatol).
None is a trial of the peptide in a cream on human skin. Two are delivery-system studies, which is itself a statement about the category: the research effort goes into getting peptides through skin at all.
Where the evidence sits in this jar
Niacinamide carries most of it. Forty-five randomized controlled trials of topical niacinamide are tagged in PubMed, against no trial isolating any of the three peptides. It is also the highest-listed active, ahead of every peptide in the declaration. Our peptide serum explainer sets out what order can and cannot tell a reader, including why every common cosmetic peptide sits at or under the 1% line.
The vitamin C is a derivative, and it is named precisely on the label. The brand describes "encapsulated ethylated vitamin C"; the declaration lists 3-O-ethyl ascorbic acid at 17, an ether of ascorbic acid made to be more stable than the parent vitamin. It has 25 title-or-abstract records in PubMed. The label does not show which ingredient does the encapsulating, and the brand does not say.
Honokiol and magnolol at 20 and 21 are the two lignans of magnolia bark. They are not mentioned in the product description.
The brand gives the formula's pH as 4.80 to 5.80.
The brand's study, as published
The product page makes one efficacy statement: the moisturizer is "clinically proven to show an improvement in the look of fines lines and wrinkles in 8 weeks," footnoted as an 8-week clinical study on women and men, with representation across all skin types and self-perceived sensitive skin.
Read on 2026-09-17, the page gives no number of participants, no measurement method, no control arm and no result figures. A statement with no headcount cannot be weighed at all. Even with one, a single-arm study of a formula containing niacinamide, a vitamin C derivative and three peptides could not say which ingredient, if any, produced a change — the question our peptide moisturizer explainer found unanswered across the whole category, where 5 of 613 moisturizer trials involved a peptide.
Alongside another peptide moisturizer
Read side by side with our analysis of Skinfix Triple Lipid-Peptide Cream, the two formulas use the word peptide for different things. Skinfix's is one mixture of rice protein fragments in a lipid-rich barrier base. Naturium's are three defined synthetic signal peptides in a lighter base led by glycerin and dimethicone, behind a B3 vitamin. Neither page ranks the two, and an ingredient list cannot.
What the label settles, and what it leaves open
It establishes three defined peptides in the upper third of the list — two of them the Matrixyl 3000 pair and one with four records, none a human trial of the peptide alone — listed after niacinamide, the active with the largest published file. It establishes a stabilised vitamin C derivative, panthenol, hyaluronic acid and magnolia lignans below them, and a published pH of 4.80 to 5.80.
It does not establish what the moisturizer does to skin, and the brand's eight-week study, as published, gives nothing to check. We have not put it on skin, and the order of names on a label cannot stand in for doing so.
Sources
- Naturium, Multi-Peptide Moisturizer — published ingredient list, product description, clinical statement and pH, naturium.com, read 2026-09-17.
- PubChem compound records read 2026-09-17: CID 936 (niacinamide), 11950477 (palmitoyl tripeptide-5), 10231864 (palmitoyl tripeptide-1), 10078408 (palmitoyl tetrapeptide-7).
- PubMed records for palmitoyl tripeptide-5: 39383579, 36985499, 34451799, 31134751.
- PubMed record counts via NCBI E-utilities, run 2026-09-17.