The Turnover Ampoule is the leave-on serum from Rejuran, the brand known for its injectable salmon-DNA skin booster. Its product page sells it on c-PDRN, the brand's name for its DNA ingredient. The US page publishes the full ingredient list and names the sources behind its clinical claims, so both can be read directly. This analysis does that, position by position. The ampoule has not been used by anyone at this journal; the page is about what the label and the cited studies say.
The declaration
Copied from rejuranusa.com, read on 4 October 2026.
| # | Ingredient | # | Ingredient |
|---|---|---|---|
| 1 | Water | 14 | Tocopheryl Acetate |
| 2 | Aloe Barbadensis Leaf Juice | 15 | Xanthan Gum |
| 3 | Butylene Glycol | 16 | Carbomer |
| 4 | PEG-6 | 17 | Caprylyl Glycol |
| 5 | Rubus Fruticosus (Blackberry) Leaf Extract | 18 | Polysorbate 20 |
| 6 | Glycerin | 19 | Hexylene Glycol |
| 7 | Niacinamide | 20 | Phenoxyethanol |
| 8 | Glycyrrhiza Glabra (Licorice) Root Extract | 21 | Benzyl Alcohol |
| 9 | Calendula Officinalis Flower Extract | 22 | (-)-alpha-Bisabolol |
| 10 | Vaccinium Angustifolium (Blueberry) Fruit Extract | 23 | Adenosine |
| 11 | Morus Nigra Fruit Extract | 24 | Arbutin |
| 12 | Sodium Hyaluronate | 25 | Ethylhexylglycerin |
| 13 | Hydrolyzed DNA |
Finding 1: the DNA is 13th of 25, and the label calls it something else
The ingredient the page is built around appears once, as Hydrolyzed DNA, at position 13. "c-PDRN" is the brand's trademark and is not an ingredient-list name. Most PDRN serums this site has read declare their DNA as Sodium DNA — ten of the twelve labels on our PDRN eye cream census did — and the ampoule's page does not say why its label uses a different name.
Above the DNA sit water, aloe juice, two glycols, glycerin, niacinamide at 7, licorice root extract at 8, three fruit and flower extracts, and sodium hyaluronate at 12. Below it come vitamin E acetate, two thickeners, the preservative system and, near the end, adenosine and arbutin.
US rules require descending order of amount only down to the 1% line; below it, ingredients may be listed in any order (21 CFR 701.3(f)(2)). Phenoxyethanol, at 20, is normally used at 1% or less, so the DNA at 13 sits above the preservatives — but the list alone cannot say whether it is above or below 1%.
Finding 2: "the highest level of c-PDRN available" has no number
The page says the formula "contains the highest level of c-PDRN available". It gives no percentage, no comparison product and no method. A shopper cannot check the claim against this label or any other, because the label states no amount for any ingredient.
The same paragraph describes c-PDRN as "a marine-based growth factor". PDRN and polynucleotides are mixtures of DNA fragments, usually from salmon or trout. Growth factors are proteins, such as the EGF declared as sh-oligopeptide-1 on some serums. Published accounts of how DNA fragments act on skin describe signalling through the adenosine A2A receptor (summarised in Ziade et al., 2026), not a growth-factor mechanism. Our PDRN explainer covers the chemistry.
Finding 3: what the clinical claims cite
| Claim on the product page | Source the page gives |
|---|---|
| Faster healing and improved scarring after burns, laser and peels | Korea Institute of Dermatological Science, 22 people, twice daily for 2 weeks |
| Improves dermal density and elasticity | "Clinical studies" — no source line |
| Increases hydration and smoothness | "Clinical studies" — no source line |
| Damage from multiple cosmetic injections "healed faster, and with better results" | In-house study, 1 volunteer, twice daily for 2 weeks |
The 22-person study is not described beyond its size and duration: the page names no comparison group, no measurement and no result in numbers. One volunteer is a case, not a study in the sense the word usually carries. Neither study is published: on 4 October 2026, PubMed held no record containing the phrase "turnover ampoule".
Finding 4: the Rejuran literature is about the needle
PubMed held 10 records naming Rejuran on 4 October 2026. The ones that test a Rejuran product test the injectable — split-face trials after radiofrequency treatment, crow's-feet comparisons against other fillers. Two are retracted: a 2014 phase III trial in the Journal of Korean Medical Science (PMID 25473210, retraction notice 26839493) and a 2025 crow's-feet comparison in the Journal of Cosmetic Dermatology (PMID 39313949, retracted in March 2026). We list what remains on our polynucleotides page.
Injected DNA and DNA in a serum are different questions. A polynucleotide gel delivered into the dermis is not limited by the skin's outer barrier; a large DNA fragment applied to the surface is. Our PDRN serum label census sets out what the topical evidence holds.
Finding 5: the other actives on the list
Two ingredients higher on the list than the DNA have larger published records of their own. Niacinamide (7th): a PubMed search for niacinamide and skin returned 144 records tagged as randomized controlled trials on 4 October 2026. Licorice root extract (8th) and arbutin (24th) are brightening ingredients, and adenosine (23rd) is one of the ingredients Korean regulators recognise in anti-wrinkle functional cosmetics (Jeon et al., 2016). The page's claims about tone and age spots are claims a niacinamide serum could also make; the label does not show which ingredient the brand's 22-person study was designed to isolate.
The legal question shoppers ask
"Is Rejuran illegal in the USA?" is one of the questions searchers attach to this product. The answer differs for the two products:
- The injectable has no record in FDA's device-approval (PMA) database: a search for the trade name returned nothing on 4 October 2026, while the same search for Juvederm returned 129 records.
- The Turnover Ampoule is a cosmetic. FDA states that "cosmetic products and ingredients do not need FDA premarket approval, with the exception of color additives." It can be sold without an approval as long as it is marketed as a cosmetic.
That boundary matters for the claims. A cosmetic may claim to improve appearance; a product claiming to heal burns is making a drug-type claim. The page phrases most claims as appearance ("diminishes the appearance of sun damage") but titles one panel "Speeds Healing".
What it costs
Listed on 4 October 2026: 30 mL at $41.60 on sale (regular $52.00), about $1.39 per mL on sale and $1.73 at the regular price; 50 mL at $57.60 on sale, about $1.15 per mL. For comparison on this site, see the per-millilitre figures on our Anua PDRN capsule serum and Medicube PDRN Pink Peptide Serum analyses.
Questions the label leaves open
- How much Hydrolyzed DNA the ampoule contains, and what "highest level" is measured against.
- What the 22-person study compared and measured.
- Why the US list says Hydrolyzed DNA where most PDRN cosmetics say Sodium DNA.
Related reading on this site
The salmon-DNA category is mapped on our skin boosters guide. For the clinic version, see polynucleotides for skin. For other serums read the same way, see the Anua PDRN serum analysis and how to read a peptide ingredient list.
Sources
- Rejuran USA, Turnover Ampoule product page and product JSON: ingredient list, claims, study source lines, prices, rejuranusa.com, read 4 October 2026.
- PubMed E-utilities searches, 4 October 2026: "turnover ampoule" (phrase not found); "rejuran" (10 records, including PMIDs 25473210 and 39313949, both tagged Retracted Publication, and retraction notices 26839493 and 41834780).
- Ziade G et al. Prospective observational study of polynucleotide injections for periorbital rhytides. Journal of Cosmetic Dermatology 2026 (PMID 41689167) — adenosine A2A mechanism as described in its introduction.
- openFDA device PMA endpoint, trade-name searches "rejuran" (no match) and "juvederm" (129 records), 4 October 2026.
- US FDA, "FDA Authority Over Cosmetics: How Cosmetics Are Not FDA-Approved, but Are FDA-Regulated", fda.gov, read 4 October 2026.
- PubMed search, 4 October 2026: niacinamide AND skin AND "randomized controlled trial"[pt] (144).
- Jeon JS et al. Simultaneous determination of water-soluble whitening ingredients and adenosine in different cosmetic formulations. International Journal of Cosmetic Science 2016 (PMID 26564311) — the Korean Cosmetic Act's functional-cosmetic groups.
- US Code of Federal Regulations, 21 CFR 701.3(f)(2) — relevant because the DNA ingredient sits 13th, where the any-order rule for ingredients at 1% or less may apply.